Most times, yes. You drill for locking the position of your controls. Some cut the nubs off, but that is not a good idea, with it's highvibration, screws can back off and you loose control of the controls.
I have not drilled any new bar yet and have not lost any screws. The worst you may experience is the kill switch housing and the horn button housing will rotate a bit but not much as there are stops on the lever mounts.
One thing I would suggest is using Loctite on the housing screws and if you don't want the housings to move, then wrap that part of the bar in electrical tape.
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